Telomerase and cancer therapeutics

@article{Harley2008TelomeraseAC,
  title={Telomerase and cancer therapeutics},
  author={Calvin B. Harley},
  journal={Nature Reviews Cancer},
  year={2008},
  volume={8},
  pages={167-179}
}
Telomerase is an attractive cancer target as it appears to be required in essentially all tumours for immortalization of a subset of cells, including cancer stem cells. Moreover, differences in telomerase expression, telomere length and cell kinetics between normal and tumour tissues suggest that targeting telomerase would be relatively safe. Clinical trials are ongoing with a potent and specific telomerase inhibitor, GRN163L, and with several versions of telomerase therapeutic vaccines. The… CONTINUE READING
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Antiadhesive effects of GRN 163 L – an oligonucleotide N 3 ′ → P 5 ′ thiophosphoramidate targeting telomerase

  • D. A. Jackson
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  • 2007

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