Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia.

  title={Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia.},
  author={Srdan Verstovsek and Francis J Giles and Susan M O'Brien and Stefan H Faderl and Hagop M Kantarjian and Michael J Keating and Maher Albitar},
  journal={Leukemia research},
  volume={28 7},
We measured telomerase activity (TA) in bone marrow samples from 214 patients with CLL and correlated it with patients' characteristics and survival. In >50% of cases (126/214; 59%) no detectable TA was found. There was no difference in TA between previously treated (n = 153) and untreated (n = 61) patients (P = 0.4), or patients with various Rai (0-IV) stages (P = 0.85). TA correlated significantly with white blood cell and lymphocyte count (P = 0.02 and 0.01, respectively) but not with bone… CONTINUE READING


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