Telomerase activity in melanoma and non-melanoma skin cancer

@article{Parris1999TelomeraseAI,
  title={Telomerase activity in melanoma and non-melanoma skin cancer},
  author={Christopher N. Parris and Sarah Jezzard and Andrew Silver and Rona M. MacKie and J. M. Mcgregor and Ronald F. Newbold},
  journal={British Journal of Cancer},
  year={1999},
  volume={79},
  pages={47 - 53}
}
SummaryTelomeres are specialized structures consisting of repeat arrays of TTAGGGn located at the ends of chromosomes. They are essential for chromosome stability and, in the majority of normal somatic cells, telomeres shorten with each cell division. Most immortalized cell lines and tumours reactivate telomerase to stabilize the shortening chromosomes. Telomerase activation is regarded as a central step in carcinogenesis and, here, we demonstrate telomerase activation in premalignant skin… CONTINUE READING

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Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma

  • International journal of molecular sciences
  • 2019
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References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Detection of telomerase activity in human cells and tumo by a telomeric repeat amplifictaion protocol (TRAP)

MA Piatyszek, NW Kim, +4 authors JW Shay
  • Methods Cell Sci
  • 1995
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Telomere shortening and tumour formation by mo cells lacking telomerase RNA

MA Blasco, H-W Lee, +4 authors CW Greider
  • 1997
VIEW 1 EXCERPT

Loss of the p 16 INK 4 a and p 15 INK 4 b genes , as well as neighboring 9 p 21 markers in sporadic melanoma

JF Flores, GJ Walker, +11 authors JW Fountain
  • Cancer Res
  • 1996
VIEW 1 EXCERPT