Telomerase activity in hepatocellular carcinoma and adjacent liver tissues.

  title={Telomerase activity in hepatocellular carcinoma and adjacent liver tissues.},
  author={Koshi N. Kishimoto and Jiro Fujimoto and M. D. Muneyuki Takeuchi and Hanako Yamamoto and Toshihito Ueki and Eizo Okamoto},
  journal={Journal of surgical oncology},
  volume={69 3},
BACKGROUND AND OBJECTIVES Activation of telomerase and stabilization of telomeres are considered necessary for immortalization of tumor cells. Telomerase activity was analyzed in 69 hepatocellular carcinomas and adjacent chronic liver disease tissues. The telomerase activity level was examined in relation to clinicopathologic features. METHODS Telomerase activity was determined by a telomeric repeat amplification protocol. Immature and mature leukocytes were removed from homogenized tissue of… CONTINUE READING


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