Telomerase activity in HeLa cervical carcinoma cell line proliferation

@article{Ivankovi2006TelomeraseAI,
  title={Telomerase activity in HeLa cervical carcinoma cell line proliferation},
  author={Milena Ivankovi{\'c} and Andrea {\'C}uku{\vs}i{\'c} and Ivana Goti{\'c} and Nikolina {\vS}krobot and Mario Matija{\vs}i{\'c} and Denis Polan{\vc}ec and Ivica Rubelj},
  journal={Biogerontology},
  year={2006},
  volume={8},
  pages={163-172}
}
Normal human somatic cells in culture have a limited dividing potential. This is due to DNA end replication problem, whereby telomeres shorten with each subsequent cell division. When a critical telomere length is reached cells enter senescence. To overcome this problem, immortal HeLa cell line express telomerase, an enzyme that prevents telomere shortening. Although immortal, the existence of non-dividing cells that do not incorporate 3H-thymidine over 24 h of growth has been well documented… Expand
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TLDR
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