Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

@article{Nakayama1998TelomeraseAB,
  title={Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas},
  author={Jun-ichi Nakayama and Hidetoshi Tahara and Eiji Tahara and Motoki Saito and Kaori Ito and Hideo Nakamura and Toshio Nakanishi and Eiichi Nakanishi and Toshinori Ide and Fuyuki Ishikawa},
  journal={Nature Genetics},
  year={1998},
  volume={18},
  pages={65-68}
}
Telomerase is a specialized type of reverse transcriptase which catalyzes the synthesis and extension of telomeric DNA (for review, see ref.1). This enzyme is highly active in most cancer cells, but is inactive in most somatic cells2. This striking observation led to the suggestion that telomerase might be important for the continued growth3 or progression4 of cancer cells. However, little is known about the molecular mechanism of telomerase activation in cancer cells. Human telomerase reverse… CONTINUE READING