Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

@article{TomsLoba2008TelomeraseRT,
  title={Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice},
  author={Antonia Tom{\'a}s-Loba and I. Flores and P. Fern{\'a}ndez-Marcos and M. L. Cayuela and A. Maraver and Agueda M. Tejera and C. Borr{\'a}s and A. Matheu and P. Klatt and J. Flores and J. Vi{\~n}a and M. Serrano and M. Blasco},
  journal={Cell},
  year={2008},
  volume={135},
  pages={609-622}
}
  • Antonia Tomás-Loba, I. Flores, +10 authors M. Blasco
  • Published 2008
  • Biology, Medicine
  • Cell
  • Telomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural ends of chromosomes, which otherwise would undergo progressive attrition and eventually compromise cell viability. However, the role of telomerase in organismal aging has remained unaddressed, in part because of the cancer-promoting activity of telomerase. To circumvent this problem, we have constitutively expressed telomerase reverse transcriptase (TERT), one of the… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 67 REFERENCES
    Constitutive telomerase expression promotes mammary carcinomas in aging mice
    286
    Extension of life-span by introduction of telomerase into normal human cells.
    4381
    Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
    1911
    Short telomeres limit tumor progression in vivo by inducing senescence.
    290
    Telomere length, stem cells and aging.
    533
    Conditional telomerase induction causes proliferation of hair follicle stem cells
    387
    Telomerase regulation during entry into the cell cycle in normal human T cells.
    171
    Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
    400