Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ

  title={Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ},
  author={Scott J. Diede and Daniel E Gottschling},
cleotide (Greider and Blackburn, 1985). Two essential components for telomerase enzymatic To better understand the requirements for telo-merase-mediated telomere addition in vivo, we devel-activity have been defined in a variety of organisms: a protein catalytic subunit with similarity to reverse tran-oped an assay in S. cerevisiae that creates a chromosome end immediately adjacent to a short telomeric scriptase and an RNA component that provides the template for telomeric DNA addition… CONTINUE READING
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