Telomerase : the reverse transcriptase subunit as a key to enzymatic function and regulation during cell immortalization

The ends of eukaryotic chromosomes are formed by non-nucleosomal DNA-protein complexes called telomeres [1]. Telomeric DNA usually consists of simple repetitive sequences that is GT-rich in the strand that points 5’-3’ towards the chromosome end. The length of telomeric tracts varies considerably among species and is typically heterogeneous. Human telomeres… CONTINUE READING