Telomerase: regulation, function and transformation.

  title={Telomerase: regulation, function and transformation.},
  author={Carolyn K. Dong and Kenkichi Masutomi and William C. Hahn},
  journal={Critical reviews in oncology/hematology},
  volume={54 2},
Work from several laboratories over the past decade indicates that the acquisition of constitutive telomerase expression is a critical step during the malignant transformation of human cells. Normal human cells transiently express low levels of telomerase, the ribonucleoprotein responsible for extending and maintaining telomeres, and exhibit telomere shortening after extended passage, whereas most cancers exhibit constitutive telomerase expression and maintain telomeres at stable lengths. These… CONTINUE READING

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