Telomerase: central regulator of all of the hallmarks of cancer.

  title={Telomerase: central regulator of all of the hallmarks of cancer.},
  author={Kee Chung Low and Vinay Tergaonkar},
  journal={Trends in biochemical sciences},
  volume={38 9},
The hallmarks of cancer described by Hanahan and Weinberg are properties that cancer cells must possess for successful transformation. It is believed that each of these hallmarks is independently driven. Although elongation of telomeres is thought to be the prime function of reactivated telomerase reverse transcriptase, this activity does not account for all its effects, such as increasing cell proliferation, resistance to apoptosis, and invasion. Recent studies suggest that the telomerase… CONTINUE READING
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