Telomerase: a potential therapeutic target for cancer.

  title={Telomerase: a potential therapeutic target for cancer.},
  author={Terace M. Fletcher},
  journal={Expert opinion on therapeutic targets},
  volume={9 3},
Telomeres are complex structures which serve to protect chromosome ends. Telomere shortening occurs in normal somatic cells reaching a point in which cells senesce. Senescence can be counteracted by activating telomerase. Telomerase activity is present in a majority of cancer cells and requires the upregulation of the reverse transcriptase component called hTERT. Because telomerase activity is essential for proliferation of most cancer cells, therapeutic strategies have been developed to… CONTINUE READING

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