Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing properties.

@article{Zanchi2007TelmisartanPT,
  title={Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing properties.},
  author={Anne Zanchi and A G Dulloo and Christine Perregaux and J. P. Montani and Michel Antoine Burnier},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 1},
  pages={
          E91-5
        }
}
Glitazones are peroxisome proliferator-activated receptor (PPAR)-gamma agonists with powerful insulin-sensitizing properties. They promote the development of metabolically active adipocytes that can lead to a substantial gain in fat mass. Telmisartan is an ANG II type 1 receptor antagonist with partial PPAR-gamma agonistic properties. Recently, telmisartan has been reported to prevent weight gain and improve insulin sensitivity in diet-induced obese rodents. The goal of this study was to… CONTINUE READING

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