Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma.

@article{Walcher2008TelmisartanIC,
  title={Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma.},
  author={Daniel Walcher and Katharina Hess and Philipp Heinz and Kerstin Petscher and Dusica Vasic and Ulrich Kintscher and Markus Clemenz and Martin M Hartge and Katrin Raps and V. Hombach and Nikolaus Marx},
  journal={Hypertension},
  year={2008},
  volume={51 2},
  pages={259-66}
}
Migration of CD4-positive lymphocytes into the vessel wall represents an important step in early atherogenesis. Telmisartan is an angiotensin type 1 receptor (AT1R) blocker with peroxisome proliferator-activated receptor (PPAR)-gamma-activating properties. The present study examined the effect of telmisartan on CD4-positive cell migration and the role of PPARgamma in this context. CD4-positive lymphocytes express both the AT1R and PPARgamma. Stimulation of CD4-positive lymphocytes with stromal… CONTINUE READING

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