Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma.

@article{Imayama2006TelmisartanDA,
  title={Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma.},
  author={Ikuyo Imayama and Toshihiro Ichiki and Keita Inanaga and Hideki Ohtsubo and Kae Fukuyama and Hiroki Ono and Yasuko Hashiguchi and Kenji Sunagawa},
  journal={Cardiovascular research},
  year={2006},
  volume={72 1},
  pages={184-90}
}
OBJECTIVE Telmisartan, an angiotensin II type 1 receptor (AT1R) antagonist, was found to have a unique property: it is a partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). Since previous studies have demonstrated that PPARgamma activators suppressed AT1R expression, we examined whether telmisartan affects AT1R expression in vascular smooth muscle cells. METHODS Vascular smooth muscle cells were derived from the thoracic aorta of Wistar-Kyoto rat. Northern and… CONTINUE READING