Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis.

@article{Sukumaran2012TelmisartanAT,
  title={Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis.},
  author={Vijayakumar Sukumaran and Punniyakoti Thanikachalam Veeraveedu and Narasimman Gurusamy and Arun Prasath Lakshmanan and Ken'ichi Yamaguchi and Meilei Ma and Kenji Suzuki and Makoto Kodama and Kenichi Watanabe},
  journal={Life sciences},
  year={2012},
  volume={90 7-8},
  pages={289-300}
}
AIM Recent findings have suggested that a therapeutic approach to amplify or stimulate the angiotensin-converting enzyme-2 [ACE-2]-angiotensin 1-7 [ANG 1-7] mas axis could provide protection against the development of cardiovascular diseases. We investigated the cardioprotective effects of telmisartan in rats with dilated cardiomyopathy [DCM] after experimental autoimmune myocarditis [EAM]. MAIN METHODS DCM was elicited in Lewis rats by immunization with cardiac myosin, and twenty-eight days… CONTINUE READING