Telmisartan Ameliorates Nephropathy in Metabolic Syndrome by Reducing Leptin Release From Perirenal Adipose Tissue

@article{Li2016TelmisartanAN,
  title={Telmisartan Ameliorates Nephropathy in Metabolic Syndrome by Reducing Leptin Release From Perirenal Adipose Tissue},
  author={Hao Li and Min Li and Ping Liu and Yaping Wang and Heng Zhang and Hongbin Li and Shi-Jiang Yang and Yan Song and YanRong Yin and Lan Gao and Si Cheng and Jun Cai and Gang Tian},
  journal={Hypertension},
  year={2016},
  volume={68},
  pages={478–490}
}
Metabolic syndrome (MetS) is associated with nephropathy. Along with common risk factors such as hypertension and hyperglycemia, adipocytokines released from perirenal adipose tissue (PRAT) are implicated in the pathogenesis of MetS nephropathy. The study was designed to elucidate the adverse effects of PRAT-derived leptin on nephropathy and to determine whether the angiotensin II type 1 receptor antagonist telmisartan exerts a renoprotective effect by decreasing the PRAT-derived leptin level… Expand
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High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17
  • Jee-in Kim
  • Medicine
  • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2017
TLDR
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TLDR
Besides its anti-hypertensive effect, telmisartan had profound actions on visceral adipose tissue structure and function, which could be the core pathophysiology of obesity-related hypertension. Expand
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A broad overview of novel insights linking cardiovascular derangements and CKD with a focus on metabolic disorders affecting PRAT is presented, arguing that the confluence among these pathways may open several perspectives for future pharmacological therapies against CKD and CVD possibly by modulating PRAT immunometabolism. Expand
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The findings show that diabetic cardiomyopathy was associated with ectopic overexpression of PPARγ2, and the full agonist rosiglitazone prevents cardiac dysfunction at the expense of compensatory hypertrophy, while the partial agonist CMHX008 shared a comparable protective effect without altering the structure of cardiomers. Expand
Expression of adipokines and their receptors in adipose tissue of women with class 3 obesity with or without hypertension.
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It was found that those women with a higher mean arterial pressure and receiving antihypertensive treatment, presented higher levels of mRNA expression of adiponectin in SAT. Expand
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The research over the past 5 years has underscored an important role of increased aldosterone and vascular mineralocorticoid receptor activation in driving development of cardiovascular stiffness, especially in females consuming a Western diet. Expand
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