Telmisartan Ameliorates Nephropathy in Metabolic Syndrome by Reducing Leptin Release From Perirenal Adipose Tissue

@article{Li2016TelmisartanAN,
  title={Telmisartan Ameliorates Nephropathy in Metabolic Syndrome by Reducing Leptin Release From Perirenal Adipose Tissue},
  author={Hao Li and Min Li and Ping Liu and Yaping Wang and Heng Zhang and Hongbin Li and Shifeng Yang and Yan Song and Yanrong Yin and Lan Gao and Si Cheng and Jiong Cai and Gang Tian},
  journal={Hypertension},
  year={2016},
  volume={68},
  pages={478–490}
}
Metabolic syndrome (MetS) is associated with nephropathy. Along with common risk factors such as hypertension and hyperglycemia, adipocytokines released from perirenal adipose tissue (PRAT) are implicated in the pathogenesis of MetS nephropathy. The study was designed to elucidate the adverse effects of PRAT-derived leptin on nephropathy and to determine whether the angiotensin II type 1 receptor antagonist telmisartan exerts a renoprotective effect by decreasing the PRAT-derived leptin level… 
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