Telavancin: an antimicrobial with a multifunctional mechanism of action for the treatment of serious gram-positive infections.

@article{Leonard2008TelavancinAA,
  title={Telavancin: an antimicrobial with a multifunctional mechanism of action for the treatment of serious gram-positive infections.},
  author={Steven N. Leonard and Michael Joseph Rybak},
  journal={Pharmacotherapy},
  year={2008},
  volume={28 4},
  pages={458-68}
}
Telavancin is a once-daily lipoglycopeptide antibiotic structurally derived from vancomycin. It has broad-spectrum activity against gram-positive bacteria, including strains with reduced susceptibility to vancomycin. Telavancin's multifunctional mechanism of action, including inhibition of peptidoglycan synthesis and disruption of membrane potential, account for this enhanced activity as well as rapid bactericidal properties. In vitro activity has been demonstrated against a wide range of gram… CONTINUE READING
14 Citations
64 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

European baseline surveillance of telavancin ’ s in vitro activity against staphylococci

  • DF Sahm, BM Benton, KM Krause
  • Antimicrob Agents Chemother
  • 2007

First susceptibility surveillance of MRSA for telavancin in Japan. Presented at the 47th interscience conference on antimicrobial agents and chemotherapy

  • K Hatano, K Matsuzaki, Y Sato, I Kobayashi, K. Yamaguchi
  • 2007

Similar Papers

Loading similar papers…