Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus.

@article{Higgins2005TelavancinAM,
  title={Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus.},
  author={Deborah L. Higgins and R. E. Chang and Dmitri V Debabov and Joey Shuk Yan Leung and Terry Wu and Kevin M. Krause and Erik R. Sandvik and Jeffrey Miller Hubbard and Kon{\'e} Kaniga and Donald Edward Schmidt and Qiufeng Gao and Robert T. Cass and Dane E. Karr and Bret M. Benton and Patrick Paul Anthony Humphrey},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 3},
  pages={
          1127-34
        }
}
The emergence and spread of multidrug-resistant gram-positive bacteria represent a serious clinical problem. Telavancin is a novel lipoglycopeptide antibiotic that possesses rapid in vitro bactericidal activity against a broad spectrum of clinically relevant gram-positive pathogens. Here we demonstrate that telavancin's antibacterial activity derives from at least two mechanisms. As observed with vancomycin, telavancin inhibited late-stage peptidoglycan biosynthesis in a substrate-dependent… CONTINUE READING
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