Telaprevir for previously untreated chronic hepatitis C virus infection.

@article{Jacobson2011TelaprevirFP,
  title={Telaprevir for previously untreated chronic hepatitis C virus infection.},
  author={Ira M. Jacobson and John McHutchison and Geoffrey Dusheiko and Adrian M Di Bisceglie and K. Venu Jayanth Reddy and Natalie H. Bzowej and Patrick Marcellin and Andrew J. Muir and Peter Ferenci and Robert Flisiak and Jennifer George and Mario Rizzetto and Daniel Shouval and Ricard Sol{\'a} and Ruben Alberto Terg and Eric M Yoshida and Nathalie Adda and Leif Bengtsson and Abdul J. Sankoh and Tara L. Kieffer and Shelley B. George and Robert S. Kauffman and Stefan Zeuzem},
  journal={The New England journal of medicine},
  year={2011},
  volume={364 25},
  pages={
          2405-16
        }
}
BACKGROUND In phase 2 trials, telaprevir, a hepatitis C virus (HCV) genotype 1 protease inhibitor, in combination with peginterferon-ribavirin, as compared with peginterferon-ribavirin alone, has shown improved efficacy, with potential for shortening the duration of treatment in a majority of patients. METHODS In this international, phase 3, randomized, double-blind, placebo-controlled trial, we assigned 1088 patients with HCV genotype 1 infection who had not received previous treatment for… CONTINUE READING

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