Tel1ATM dictates the replication timing of short yeast telomeres

Abstract

Telomerase action is temporally linked to DNA replication. Although yeast telomeres are normally late replicating, telomere shortening leads to early firing of subtelomeric DNA replication origins. We show that double-strand breaks flanked by short telomeric arrays cause origin firing early in S phase at late-replicating loci and that this effect on origin… (More)
DOI: 10.15252/embr.201439242

5 Figures and Tables

Topics

  • Presentations referencing similar topics