Teixobactin: A Paving Stone towards A New Class of Antibiotics?

  title={Teixobactin: A Paving Stone towards A New Class of Antibiotics?},
  author={Vidya B. Gunjal and Ritesh P Thakare and Sidharth Chopra and D. Srinivasa Reddy},
  journal={Journal of medicinal chemistry},
Antimicrobial resistance is a serious threat to human health worldwide, prompting research efforts on a massive scale in search of novel antibiotics to fill an urgent need for a remedy. Teixobactin, a macrocyclic depsipeptide natural product, isolated from uncultured bacteria (Eleftheria terrae), displayed potent activity against several Gram-positive pathogenic bacteria. The distinct pharmacological profile and interesting structural features of teixobactin with non-standard amino acid (three… 
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Teixobactin: a novel anti-infective agent
  • M. McCarthy
  • Biology
    Expert review of anti-infective therapy
  • 2019
The discovery and development of teixobactin and its analogs are reviewed to explore how they may serve as an example for other novel compounds that are in development to address the expanding problem of antimicrobial drug resistance.
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Total synthesis of teixobactin
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