Teixobactin: A Paving Stone towards A New Class of Antibiotics?

@article{Gunjal2020TeixobactinAP,
  title={Teixobactin: A Paving Stone towards A New Class of Antibiotics?},
  author={Vidya B. Gunjal and Ritesh P Thakare and Sidharth Chopra and D. Srinivasa Reddy},
  journal={Journal of medicinal chemistry},
  year={2020}
}
Antimicrobial resistance is a serious threat to human health worldwide, prompting research efforts on a massive scale in search of novel antibiotics to fill an urgent need for a remedy. Teixobactin, a macrocyclic depsipeptide natural product, isolated from uncultured bacteria (Eleftheria terrae), displayed potent activity against several Gram-positive pathogenic bacteria. The distinct pharmacological profile and interesting structural features of teixobactin with non-standard amino acid (three… 
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9 Citations

Prospects for Antibacterial Discovery and Development.
TLDR
This Perspective makes the case that, in the face of evolving clinical needs and enabling technologies, numerous validated antibacterial targets and associated lead molecules deserve a second look, and highlights available pharmacoeconomic models for antibacterial discovery and development while making the case for new ones.
Nanotechnologies in the Light of Modern Antibacterial Strategies: A Review
TLDR
It is concluded that these innovative platforms certainly merit attention and further study as alternative means of preventing and treating bacterial infections, and the main limitation for the clinical use of modern nanomaterials is the need for further assessment of their safety and cytotoxicity.
Antimicrobial Effects of L-Chg10-Teixobactin against Enterococcus faecalis In Vitro
TLDR
L-Chg10-teixobactin demonstrated potent antibacterial and antibiofilm effects against E. faecalis, suggesting its potential role an effective antib bacterial and antibiosfilm agent in endodontic treatment.
Into the Unknown: Microbial Communities in Caves, Their Role, and Potential Use
TLDR
Bacteria that can induce mineral precipitation could be used in the construction industry and for neutralization of radioisotopes, and their biotechnological and medical potential are reviewed.
Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds
Trends in peptide drug discovery
TLDR
This Perspective summarizes trends in peptide drug discovery, emphasizing lessons from earlier approaches as well as emerging strategies such as integrated venomics and peptide-display libraries, and analyses the remaining challenges and the pharmaceutical landscape in which peptide drugs are particularly valuable.
Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM
TLDR
Cryogenic transmission electron microscopy is used to show that at 1 mg/mL, teixobactin forms sheet-like assemblies that selectively act upon the cell wall, and aggregates are formed either transiently or sparingly at the cell surface.
Photo-induced radical thiol-ene chemistry: a versatile toolbox for peptide-based drug design.
TLDR
There has been a revival of interest in photoinduced radical thiol-ene chemistry as a powerful tool for the construction of therapeutic peptides for peptide modification.
Discovery, Optimization, and Clinical Application of Natural Antimicrobial Peptides
TLDR
The discovery path of AMPs is summarized, focusing on preclinical development, recent advances in chemical optimization and peptide delivery systems, and their introduction into the market.

References

SHOWING 1-10 OF 60 REFERENCES
Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis
TLDR
This review highlights the presence of enduracididine in natural products, its biosynthesis together with a review of analogues of endURacididine, illustrating the challenges encountered to date in the development of efficient synthetic routes to facilitate drug discovery efforts inspired by the discovery of teixobactin.
Teixobactin: a novel anti-infective agent
  • M. McCarthy
  • Biology
    Expert review of anti-infective therapy
  • 2019
TLDR
The discovery and development of teixobactin and its analogs are reviewed to explore how they may serve as an example for other novel compounds that are in development to address the expanding problem of antimicrobial drug resistance.
Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery.
TLDR
Teixobactin, a cyclic undecapeptide, displays excellent antibacterial activities against a range of pathogenic bacteria, such as methicillin-resistant Staphylococcus aureus and Mycobacterium tuberculosis.
Synthesis and structure−activity relationships of teixobactin
TLDR
This review provides a comprehensive treatise on the progress in understanding teixobactin chemistry, structure−activity relationships, and mechanisms of antibacterial activity.
Multiple attack on bacteria by the new antibiotic teixobactin.
TLDR
In the search for new antibacterial leads against Grampositive pathogens, the appreciation of teixobactin as a new milestone is very plausible, but it is questionable whether antibiotics without the risk of emerging resistances are a realistic scenario.
Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
TLDR
A one-pot reaction to conveniently construct the key building block l-allo-Enduracidine in 30-gram scale in just one hour and a convergent strategy to accomplish a gram-scale total synthesis of teixobactin are developed and found two potent analogous.
Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study.
Rational Design and Synthesis of Modified Teixobactin Analogues: In Vitro Antibacterial Activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa.
TLDR
Significantly, the antimicrobial activity of several of the teixobactin analogues against the pathogenic Gram-negative Pseudomonas aeruginosa was "restored" when combined with the sub-MIC concentration of the outer membrane-disruptive antibiotic colistin.
Total synthesis of teixobactin
TLDR
Teixobactin is reported as a promising first-in-class drug candidate for clinical development by a highly convergent Ser ligation approach and this strategy allows for several analogues of the natural product to be prepared.
In Vitro Antibacterial Activity of Teixobactin Derivatives on Clinically Relevant Bacterial Isolates
TLDR
Teixobactin derivatives (3, 4, and 5) inhibited bacterial growth in drug-resistant bacteria and hence emerge as potential antimicrobial agents.
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