Teixobactin: A Paving Stone towards A New Class of Antibiotics?

@article{Gunjal2020TeixobactinAP,
  title={Teixobactin: A Paving Stone towards A New Class of Antibiotics?},
  author={Vidya B. Gunjal and Ritesh P Thakare and Sidharth Chopra and D. Srinivasa Reddy},
  journal={Journal of medicinal chemistry},
  year={2020}
}
Antimicrobial resistance is a serious threat to human health worldwide, prompting research efforts on a massive scale in search of novel antibiotics to fill an urgent need for a remedy. Teixobactin, a macrocyclic depsipeptide natural product, isolated from uncultured bacteria (Eleftheria terrae), displayed potent activity against several Gram-positive pathogenic bacteria. The distinct pharmacological profile and interesting structural features of teixobactin with non-standard amino acid (three… 
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References

SHOWING 1-10 OF 60 REFERENCES
Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis
TLDR
This review highlights the presence of enduracididine in natural products, its biosynthesis together with a review of analogues of endURacididine, illustrating the challenges encountered to date in the development of efficient synthetic routes to facilitate drug discovery efforts inspired by the discovery of teixobactin.
Teixobactin: a novel anti-infective agent
  • M. McCarthy
  • Biology
    Expert review of anti-infective therapy
  • 2019
TLDR
The discovery and development of teixobactin and its analogs are reviewed to explore how they may serve as an example for other novel compounds that are in development to address the expanding problem of antimicrobial drug resistance.
Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery.
TLDR
Teixobactin, a cyclic undecapeptide, displays excellent antibacterial activities against a range of pathogenic bacteria, such as methicillin-resistant Staphylococcus aureus and Mycobacterium tuberculosis.
Synthesis and structure−activity relationships of teixobactin
TLDR
This review provides a comprehensive treatise on the progress in understanding teixobactin chemistry, structure−activity relationships, and mechanisms of antibacterial activity.
Multiple attack on bacteria by the new antibiotic teixobactin.
TLDR
In the search for new antibacterial leads against Grampositive pathogens, the appreciation of teixobactin as a new milestone is very plausible, but it is questionable whether antibiotics without the risk of emerging resistances are a realistic scenario.
Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
TLDR
A one-pot reaction to conveniently construct the key building block l-allo-Enduracidine in 30-gram scale in just one hour and a convergent strategy to accomplish a gram-scale total synthesis of teixobactin are developed and found two potent analogous.
Rational Design and Synthesis of Modified Teixobactin Analogues: In Vitro Antibacterial Activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa.
TLDR
Significantly, the antimicrobial activity of several of the teixobactin analogues against the pathogenic Gram-negative Pseudomonas aeruginosa was "restored" when combined with the sub-MIC concentration of the outer membrane-disruptive antibiotic colistin.
Total synthesis of teixobactin
TLDR
Teixobactin is reported as a promising first-in-class drug candidate for clinical development by a highly convergent Ser ligation approach and this strategy allows for several analogues of the natural product to be prepared.
In Vitro Antibacterial Activity of Teixobactin Derivatives on Clinically Relevant Bacterial Isolates
TLDR
Teixobactin derivatives (3, 4, and 5) inhibited bacterial growth in drug-resistant bacteria and hence emerge as potential antimicrobial agents.
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