Teixobactin: A Paving Stone towards A New Class of Antibiotics?

@article{Gunjal2020TeixobactinAP,
  title={Teixobactin: A Paving Stone towards A New Class of Antibiotics?},
  author={Vidya B. Gunjal and Ritesh P. Thakare and Sidharth Chopra and D. Srinivasa Reddy},
  journal={Journal of medicinal chemistry},
  year={2020}
}
Antimicrobial resistance is a serious threat to human health worldwide, prompting research efforts on a massive scale in search of novel antibiotics to fill an urgent need for a remedy. Teixobactin, a macrocyclic depsipeptide natural product, isolated from uncultured bacteria (Eleftheria terrae), displayed potent activity against several Gram-positive pathogenic bacteria. The distinct pharmacological profile and interesting structural features of teixobactin with non-standard amino acid (three… 
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This Perspective summarizes trends in peptide drug discovery, emphasizing lessons from earlier approaches as well as emerging strategies such as integrated venomics and peptide-display libraries, and analyses the remaining challenges and the pharmaceutical landscape in which peptide drugs are particularly valuable.
Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM
TLDR
Cryogenic transmission electron microscopy is used to show that at 1 mg/mL, teixobactin forms sheet-like assemblies that selectively act upon the cell wall, and aggregates are formed either transiently or sparingly at the cell surface.
Photo-induced radical thiol-ene chemistry: a versatile toolbox for peptide-based drug design.
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There has been a revival of interest in photoinduced radical thiol-ene chemistry as a powerful tool for the construction of therapeutic peptides for peptide modification.

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