Teicoplanin pharmacokinetics in critically ill patients on continuous veno-venous hemofiltration.

@article{Bellmann2010TeicoplaninPI,
  title={Teicoplanin pharmacokinetics in critically ill patients on continuous veno-venous hemofiltration.},
  author={Romuald Bellmann and Gerda Falkensammer and Christoph Seger and Stefan Weiler and Jordan Kountchev and Michael Joannidis},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2010},
  volume={48 4},
  pages={
          243-9
        }
}
Pharmacokinetics of teicoplanin (TP) was assessed in critically ill patients on continuous veno-venous hemofiltration (CVVH), in eleven patients, after the first dose and in another four after repeated administration. The TP peak concentration amounted to 55.44 +/- 15.90 microg/ml and 81.28 +/- 28.55 microg/ml (mean +/- SD), the trough concentration 6.4 +/- 1.7 microg/ml and 21.3 +/- 5.0 microg/ml, the half-life 15.7 +/- 5.7 and 35.1 +/- 12.3 h, the apparent volume of distribution 0.84 +/- 0.22… CONTINUE READING