Teicoplanin biosynthesis: unraveling the interplay of structural, regulatory, and resistance genes

@article{Yushchuk2020TeicoplaninBU,
  title={Teicoplanin biosynthesis: unraveling the interplay of structural, regulatory, and resistance genes},
  author={Oleksandr Yushchuk and Bohdan Ostash and Andrew W. Truman and Flavia Marinelli and Victor Fedorenko},
  journal={Applied Microbiology and Biotechnology},
  year={2020},
  volume={104},
  pages={3279-3291}
}
Teicoplanin (Tcp) is a clinically relevant glycopeptide antibiotic (GPA) that is produced by the actinobacterium Actinoplanes teichomyceticus. Tcp is a front-line therapy for treating severe infections caused by multidrug-resistant Gram-positive pathogens in adults and infants. In this review, we provide a detailed overview of how Tcp is produced by A. teichomyceticus by describing Tcp biosynthesis, regulation, and resistance. We summarize the knowledge gained from in vivo and in vitro studies…