Teichoic acid biosynthesis as an antibiotic target.

  title={Teichoic acid biosynthesis as an antibiotic target.},
  author={Lincoln W Pasquina and John P Santa Maria and Suzanne Walker},
  journal={Current opinion in microbiology},
  volume={16 5},
The relentless spread of antibiotic-resistant pathogens makes it imperative to develop new chemotherapeutic strategies to overcome infection. The bacterial cell wall has served as a rich source for both validated and unexploited pathways that are essential for virulence and survival. Lipoteichoic acids (LTAs) and wall teichoic acids (WTAs) are cell wall polymers that play fundamental roles in Gram-positive bacterial physiology and pathogenesis, and both have been proposed as novel antibacterial… CONTINUE READING