Tegaserod: a new 5-HT(4) agonist in the treatment of irritable bowel syndrome.

@article{Corsetti2002TegaserodAN,
  title={Tegaserod: a new 5-HT(4) agonist in the treatment of irritable bowel syndrome.},
  author={Maura Corsetti and Jan Tack},
  journal={Expert opinion on pharmacotherapy},
  year={2002},
  volume={3 8},
  pages={1211-8}
}
Tegaserod is a selective partial agonist acting on serotonergic type 4 receptors (5-HT(4)). Pharmacodynamic studies indicate that tegaserod is able to stimulate gut propulsion and secretion with a net prokinetic effect. In contrast to other 5-HT(4) agonists endowed with a complex pharmacological profile, tegaserod has a reliable prokinetic activity in the colon. Clinical trials show that tegaserod is effective and safe in the treatment of patients with irritable bowel syndrome. In particular… CONTINUE READING