Tedisamil blocks single large-conductance Ca2+-activated K+ channels in membrane patches from smooth muscle cells of the guinea-pig portal vein

@article{Pfrnder1991TedisamilBS,
  title={Tedisamil blocks single large-conductance Ca2+-activated K+ channels in membrane patches from smooth muscle cells of the guinea-pig portal vein},
  author={Dietmar Pfr{\"u}nder and Volker A. W. Kreye},
  journal={Pfl{\"u}gers Archiv},
  year={1991},
  volume={418},
  pages={308-312}
}
Enzymatically dispersed smooth muscle cells of the guinea-pig portal vein were studied by the patch-clamp technique. They were found to have Ca2+-dependent K+ channels with the typical properties of the “BK” channel, i.e. a reversal potential at the calculated equilibrium potential for K+ ions, a striking voltage dependence, and a conductance of approximately 200 pS ([K+]0 50 mM, [K+]i 150 mM, positive patch potentials). Tedisamil, a new bradycardic agent with an inhibitory action on K… CONTINUE READING
12 Citations
24 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Cardiovascular profile of KC 8857 in comparison with other cardioactive agents

  • UG Kfihl, G Buschmann
  • J Mol Cell Cardiol
  • 1987

Electrophysiological profile of KC 8857, a new bradycardic agent

  • B Oexle, J Weirich, H Antoni
  • J Mol Cell Cardio119 [Suppl
  • 1987
1 Excerpt

KC 8857, a new compound with combined bradycardic and positive inotropic effects

  • F Duchosal, LH Opie
  • J Mol Cell Cardiol
  • 1987

Similar Papers

Loading similar papers…