Tedisamil and dofetilide‐induced torsades de pointes, rate and potassium dependence

  title={Tedisamil and dofetilide‐induced torsades de pointes, rate and potassium dependence},
  author={T. D. Barrett and J. Hennan and P. Fischbach and B. O'Neill and E. Driscoll and B. Lucchesi},
  journal={British Journal of Pharmacology},
  • T. D. Barrett, J. Hennan, +3 authors B. Lucchesi
  • Published 2001
  • Medicine
  • British Journal of Pharmacology
  • Tedisamil is a bradycardiac agent that prolongs the QT interval of the ECG and prevents cardiac arrhythmias. Given this profile, tedisamil might be expected to have proarrhythmic actions similar to Class III antiarrhythmic drugs. To address this question, the actions of dofetilide and tedisamil were examined in rabbit isolated hearts in which bradycardia was induced by AV ablation. The QT interval was prolonged in a reverse rate‐dependent fashion by dofetilide (3 and 30 nM) and tedisamil (0.3… CONTINUE READING
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