Tedisamil and dofetilide‐induced torsades de pointes, rate and potassium dependence

@article{Barrett2001TedisamilAD,
  title={Tedisamil and dofetilide‐induced torsades de pointes, rate and potassium dependence},
  author={T. D. Barrett and J. Hennan and P. Fischbach and B. O'Neill and E. Driscoll and B. Lucchesi},
  journal={British Journal of Pharmacology},
  year={2001},
  volume={132}
}
  • T. D. Barrett, J. Hennan, +3 authors B. Lucchesi
  • Published 2001
  • Medicine
  • British Journal of Pharmacology
  • Tedisamil is a bradycardiac agent that prolongs the QT interval of the ECG and prevents cardiac arrhythmias. Given this profile, tedisamil might be expected to have proarrhythmic actions similar to Class III antiarrhythmic drugs. To address this question, the actions of dofetilide and tedisamil were examined in rabbit isolated hearts in which bradycardia was induced by AV ablation. The QT interval was prolonged in a reverse rate‐dependent fashion by dofetilide (3 and 30 nM) and tedisamil (0.3… CONTINUE READING
    21 Citations

    Topics from this paper.

    Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia‐induced arrhythmias in rats
    • 12
    Tedisamil: a new novel antiarrhythmic
    • 12
    Torsades de Pointes in the Guinea-Pig Heart
    Antiarrhythmic Drugs:
    • D. Roden
    • Medicine
    • Journal of cardiovascular electrophysiology
    • 2003
    • 1
    • PDF
    Antiarrhythmic Drugs:
    • 20

    References

    SHOWING 1-10 OF 52 REFERENCES
    Cardiac electrophysiologic and antiarrhythmic actions of tedisamil.
    • 35
    Antiarrhythmic properties of tedisamil (KC8857), a putative transient outward K+ current blocker
    • 67
    • Highly Influential
    Effects of tedisamil (KC‐8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart
    • 26
    Influence of Tedisamil on the Initiation and Maintenance of Ventricular Fibrillation: Chemical Defibrillation by Ito Blockade?
    • 70
    • Highly Influential
    Tedisamil Attenuates Ventricular Fibrillation in a Conscious Canine Model of Sudden Cardiac Death
    • 11
    Tedisamil in a chronic canine model of atrial flutter.
    • 15
    Antiarrhythmic and Electrophysiologic Effects of Ibutilide in a Chronic Canine Model of Atrial Flutter
    • 38
    Comparative Assessment of Ibutilide, D‐Sotalol, Clofilium, E‐4031, and UK‐68, 798 in a Rabbit Model of Proarrhythmia
    • 95
    Experimental models of torsades de pointes
    • 53