Technology evaluation: naked DNA.

@article{Ilan1999TechnologyEN,
  title={Technology evaluation: naked DNA.},
  author={Yaron Ilan},
  journal={Current opinion in molecular therapeutics},
  year={1999},
  volume={1 1},
  pages={116-20}
}
  • Yaron Ilan
  • Published 1999 in Current opinion in molecular therapeutics
Vical and Merck are investigating vaccines against hepatitis B which use Vical's patented naked DNA technology. Both therapeutic and prophylactic vaccines are under development [177132], [268397]. The technology, and subsequent collaboration, stems from the observation by Vical that by directly injecting exogenous cDNA into muscle tissue, protein is expressed which gives rise to a strong immune response and protective immunity [163222]. 

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