Technologies for imaging neural activity in large volumes

  title={Technologies for imaging neural activity in large volumes},
  author={Na Ri Ji and Jeremy Freeman and Spencer L Smith},
  journal={Nature Neuroscience},
Neural circuitry has evolved to form distributed networks that act dynamically across large volumes. Conventional microscopy collects data from individual planes and cannot sample circuitry across large volumes at the temporal resolution relevant to neural circuit function and behaviors. Here we review emerging technologies for rapid volume imaging of neural circuitry. We focus on two critical challenges: the inertia of optical systems, which limits image speed, and aberrations, which restrict… CONTINUE READING