Technologies for enhanced efficacy of DNA vaccines.

  title={Technologies for enhanced efficacy of DNA vaccines.},
  author={Fadi Saade and Nikolai Petrovsky},
  journal={Expert review of vaccines},
  volume={11 2},
Despite many years of research, human DNA vaccines have yet to fulfill their early promise. Over the past 15 years, multiple generations of DNA vaccines have been developed and tested in preclinical models for prophylactic and therapeutic applications in the areas of infectious disease and cancer, but have failed in the clinic. Thus, while DNA vaccines have achieved successful licensure for veterinary applications, their poor immunogenicity in humans when compared with traditional protein-based… CONTINUE READING
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