Technical innovations for the automated identification of gel-separated proteins by MALDI-TOF mass spectrometry.

@article{Jahn2006TechnicalIF,
  title={Technical innovations for the automated identification of gel-separated proteins by MALDI-TOF mass spectrometry.},
  author={Olaf Jahn and Doerte Hesse and Marina Reinelt and Hartmut D. Kratzin},
  journal={Analytical and bioanalytical chemistry},
  year={2006},
  volume={386 1},
  pages={
          92-103
        }
}
The combination of gel-based two-dimensional protein separations with protein identification by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is the workhorse for the large-scale analyses of proteomes. Such high-throughput proteomic approaches require automation of all post-separation steps and the in-gel digest of proteins especially is often the bottleneck in the protein identification workflow. With the objective of reaching the same high… CONTINUE READING
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