Technical challenges in using human induced pluripotent stem cells to model disease.

@article{Saha2009TechnicalCI,
  title={Technical challenges in using human induced pluripotent stem cells to model disease.},
  author={K. Saha and R. Jaenisch},
  journal={Cell stem cell},
  year={2009},
  volume={5 6},
  pages={
          584-95
        }
}
  • K. Saha, R. Jaenisch
  • Published 2009
  • Biology, Medicine
  • Cell stem cell
  • Reprogramming of human somatic cells uses readily accessible tissue, such as skin or blood, to generate embryonic-like induced pluripotent stem cells (iPSCs). This procedure has been applied to somatic cells from patients who are classified into a disease group, thus creating "disease-specific" iPSCs. Here, we examine the challenges and assumptions in creating a disease model from a single cell of the patient. Both the kinetics of disease onset and progression as well as the spatial… CONTINUE READING
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    References

    SHOWING 1-10 OF 152 REFERENCES
    New strategies to generate induced pluripotent stem cells.
    • 63
    Prospects for pluripotent stem cell‐derived cardiomyocytes in cardiac cell therapy and as disease models
    • 84
    Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells
    • 470
    • PDF
    Generation of induced pluripotent stem cells from human cord blood.
    • 440
    Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
    • 12,123
    • Highly Influential
    • PDF
    Reprogramming of human somatic cells to pluripotency with defined factors
    • 2,717
    • PDF
    Generation of human induced pluripotent stem cells from dermal fibroblasts
    • 1,003
    • PDF
    Genetic modification of human embryonic stem cells for derivation of target cells.
    • 117
    Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors
    • 1,464
    • PDF