• DOI:10.1016/j.stem.2009.11.009
Corpus ID: 14997309

Technical challenges in using human induced pluripotent stem cells to model disease.

@article{Saha2009TechnicalCI,
  title={Technical challenges in using human induced pluripotent stem cells to model disease.},
  author={K. Saha and R. Jaenisch},
  journal={Cell stem cell},
  year={2009},
  volume={5 6},
  pages={
          584-95
        }
}

K. Saha, R. Jaenisch

Published 2009

Biology, Medicine

Cell stem cell

Reprogramming of human somatic cells uses readily accessible tissue, such as skin or blood, to generate embryonic-like induced pluripotent stem cells (iPSCs). This procedure has been applied to somatic cells from patients who are classified into a disease group, thus creating "disease-specific" iPSCs. Here, we examine the challenges and assumptions in creating a disease model from a single cell of the patient. Both the kinetics of disease onset and progression as well as the spatial… CONTINUE READING

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