Technical approaches to correction of oocyte aneuploidy.

  title={Technical approaches to correction of oocyte aneuploidy.},
  author={Gianpiero D. Palermo and Takumi Takeuchi and Zev Rosenwaks},
  journal={Human reproduction},
  volume={17 8},
BACKGROUND This study describes the technical approaches used in treatment of age-related oocyte aneuploidy, the efficiency of each step of nuclear transplantation into mouse and human oocytes, and the ability of germinal vesicle (GV) transplantation to restore artificially induced ooplasmic damage. Finally, it examines the possibility of constructing viable female gametes by transferring diploid somatic cell nuclei into enucleated oocytes. METHODS GV stage mouse oocytes were collected from… CONTINUE READING


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