Technical advancement in regulatory T cell isolation and characterization using CD127 expression in patients with malignant glioma treated with autologous dendritic cell vaccination.

@article{Ardon2010TechnicalAI,
  title={Technical advancement in regulatory T cell isolation and characterization using CD127 expression in patients with malignant glioma treated with autologous dendritic cell vaccination.},
  author={Hilko Ardon and Bert Verbinnen and Wim Maes and Thomas Beez and Stefaan Van Gool and Steven de Vleeschouwer},
  journal={Journal of immunological methods},
  year={2010},
  volume={352 1-2},
  pages={169-73}
}
We have successfully treated over two hundred high-grade glioma (HGG) patients with immunotherapy consisting of vaccination with autologous dendritic cells (DCs) loaded with autologous tumour lysate. It has been documented that regulatory T cells (Treg) can counteract anti-tumour immune responses. Therefore, monitoring of Treg in these patients is essential. Up till now, Treg have been characterized based on the expression of the transcription factor Foxp3. Here, we validated IL-7 receptor… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 14 references

Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2008
View 1 Excerpt

Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2008
View 2 Excerpts

CD 127 expression inversely correlates with FoxP 3 and suppressive function of human CD 4 + Treg cells 60

W. Liu, A. L. Putnam, +11 authors J. A. Bluestone
J . Exp . Med . • 2006
View 3 Excerpts

Similar Papers

Loading similar papers…