Technical advance: soluble OX40 molecule mimics regulatory T cell modulatory activity on FcεRI-dependent mast cell degranulation.

Abstract

Tregs play a central role in modulating FcεRI-dependent MC effector functions in the course of the allergic response. Cellular interaction depends on the constitutive expression of OX40 on Tregs and the OX40L counterpart on MCs. Study of OX40L signaling on MCs is hampered by the need of a highly purified molecule, which triggers OX40L specifically. We now… (More)
DOI: 10.1189/jlb.1210651

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Cite this paper

@article{Sibilano2011TechnicalAS, title={Technical advance: soluble OX40 molecule mimics regulatory T cell modulatory activity on FcεRI-dependent mast cell degranulation.}, author={Riccardo Sibilano and Giorgia Gri and Barbara Frossi and Claudio Tripodo and Ryo Suzuki and Juan A Rivera and Andrew Macdonald and Carlo E Pucillo}, journal={Journal of leukocyte biology}, year={2011}, volume={90 4}, pages={831-8} }