Technical advance: Caspase-1 activation and IL-1β release correlate with the degree of lysosome damage, as illustrated by a novel imaging method to quantify phagolysosome damage.

@article{Davis2010TechnicalAC,
  title={Technical advance: Caspase-1 activation and IL-1β release correlate with the degree of lysosome damage, as illustrated by a novel imaging method to quantify phagolysosome damage.},
  author={Michael J Davis and Joel A Swanson},
  journal={Journal of leukocyte biology},
  year={2010},
  volume={88 4},
  pages={813-22}
}
In addition to the lysosome's important roles in digestion, antigen processing, and microbial destruction, lysosome damage in macrophages can trigger cell death and release of the inflammatory cytokine IL-1β. To examine the relationship among endocytosis, lysosome damage, and subsequent events, such as caspase-1 activation and IL-1β secretion, we developed a method for measuring lysosome disruption inside individual living cells, which quantifies release of Fdx from lysosomes. Unperturbed… CONTINUE READING
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…