Technetium-99m-tetrofosmin as a substrate for P-glycoprotein: in vitro studies in multidrug-resistant breast tumor cells.

@article{Ballinger1996Technetium99mtetrofosminAA,
  title={Technetium-99m-tetrofosmin as a substrate for P-glycoprotein: in vitro studies in multidrug-resistant breast tumor cells.},
  author={James R. Ballinger and J Bannerman and I Boxen and Patricia Firby and Neil Godfried Hartman and Malcolm J. Moore},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1996},
  volume={37 9},
  pages={1578-82}
}
UNLABELLED The accumulation of 99mTc-tetrofosmin (TFos) was studied in wildtype (WT) and doxorubicin-resistant (AdrR) variants of the rat MatB and human MCF-7 breast tumor cell lines to determine whether TFos, like 99mTc-sestamibi (MIBI), is a substrate for P-glycoprotein (P-gp), a multidrug-resistance transporter. METHODS The time course of accumulation of TFos and MIBI in WT and AdrR cells over 1 hr was studied using single-cell suspensions at 1 x 10(6) cells/ml incubated at 37 degrees C in… CONTINUE READING