Technetium-99m RP527, a GRP analogue for visualisation of GRP receptor-expressing malignancies: a feasibility study

@article{Wiele2000Technetium99mRA,
  title={Technetium-99m RP527, a GRP analogue for visualisation of GRP receptor-expressing malignancies: a feasibility study},
  author={Christophe Van De Wiele and Filip Dumont and Rudi Vanden Broecke and Wim Oosterlinck and Veronique F J Cocquyt and Rudolphe F Serreyn and S. Peers and John R. Thornback and Guido Slegers and Rudi A. Dierckx},
  journal={European Journal of Nuclear Medicine},
  year={2000},
  volume={27},
  pages={1694-1699}
}
Gastrin-releasing peptide (GRP) receptor scintigraphy could allow prediction of response to GRP receptor-targeted treatment options, early non-invasive diagnosis and in vivo prognostic stratification of GRP receptor-positive tumours. This study reports on the imaging characteristics and efficacy for tumour detection of technetium-99m RP527, a 99mTc chelated targeting peptide derived from bombesin, which binds GRP receptors with high affinity. Ten patients (four men and six women, mean age 56.4… CONTINUE READING