Technetium-99m-L,L-ethylenedicysteine: a renal imaging agent. I. Labeling and evaluation in animals.

@article{Verbruggen1992Technetium99mLLethylenedicystei,
  title={Technetium-99m-L,L-ethylenedicysteine: a renal imaging agent. I. Labeling and evaluation in animals.},
  author={Alfons Michel Verbruggen and Dennis Nosco and C G Van Nerom and Guy Bormans and Paul Adriaens and M J de Roo},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1992},
  volume={33 4},
  pages={551-7}
}
L,L-ethylenedicysteine (L,L-EC) can be labeled efficiently with 99mTc at pH 12 to obtain a highly pure and very stable tracer agent (99mTc-L,L-EC). The biological behavior of 99mTc-L,L-EC was studied in mice and a baboon. In mice, 99mTc-L,L-EC demonstrated a more rapid urinary excretion and less retention in the kidneys, the liver, the intestines, and the blood than did 99mTc-MAG3 at 10 and 60 min p.i. Urinary excretion decreased in probenecid pretreated mice, which indicates active tubular… CONTINUE READING

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