Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.

@article{Tang1994TecKA,
  title={Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.},
  author={Betty K. P. Tang and Hiroyuki Mano and Taolin Yi and James N. Ihle},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 12},
  pages={8432-7}
}
Stem cell factor (SCF) plays a crucial role in hematopoiesis through its interaction with the receptor tyrosine kinase c-kit. However, the signaling events that are activated by this interaction and involved in the control of growth or differentiation are not completely understood. We demonstrate here that Tec, a cytoplasmic, src-related kinase, physically associates with c-kit through a region that contains a proline-rich motif, amino terminal of the SH3 domain. Following SCF binding, Tec is… CONTINUE READING

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