Tears as the best practical indicator of the unbound fraction of an anticonvulsant drug.

@article{Monaco1979TearsAT,
  title={Tears as the best practical indicator of the unbound fraction of an anticonvulsant drug.},
  author={Francesco Di Monaco and Roberto Mutani and Camillo Mastropaolo and Massimo Tondi},
  journal={Epilepsia},
  year={1979},
  volume={20 6},
  pages={705-10}
}
Phenobarbital and carbamazepine concentrations were determined by the EMIT technique in tears, saliva, cerebrospinal fluid (CSF), and plasma of patients with epilepsy. Closer correlation was shown between tear/plasma and tear/CSF ratios than between saliva/plasma and saliva/CSF ratios for the two agents. The phenobarbital CSF/serum ratio was in good… CONTINUE READING