Tear and serum interleukin-8 and serum CX3CL1, CCL2 and CCL5 in sulfur mustard eye-exposed patients.

  title={Tear and serum interleukin-8 and serum CX3CL1, CCL2 and CCL5 in sulfur mustard eye-exposed patients.},
  author={Tooba Ghazanfari and Hassan Ghasemi and Roya Yaraee and Mahmoud Mahmoudi and Mohammad Ali Javadi and Mohammad Reza Soroush and Soghrat Faghihzadeh and Ali Mohammad Mohseni Majd and Raheleh Shakeri and Mahmoud Babaei and Fatemeh Heidary and Zuhair Mohammad Hassan},
  journal={International immunopharmacology},
BACKGROUND The serum and tear levels of four inflammatory chemokines were evaluated in sulfur mustard (SM)-exposed with serious ocular problems. MATERIALS AND METHODS In this study, 128 SM-exposed patients and 31 healthy control participants participated. Tear and serum levels of chemokines were assessed by ELISA method. RESULTS There was no significant difference in the serum level of IL-8/CXCL8, CX3CL1/fractalkine, CCL2/MCP-1, and CCL5/RANTES between all SM-exposed subjects and control… 
1 Citations
Therapeutic measures for sulfur mustard-induced ocular injury.
This review focuses on treatment experience carried out in humans and studied in animal models, for both SM-induced ocular acute injury and late pathology, and investigates the potential of additional pharmacological and biological treatments or advanced cellular and molecular biology methods to serve as novel therapeutic measures and techniques for this complicated ocular injury.


Evaluation of the tear and serum levels of IL-8 in sulfur mustard intoxicated patients 20 years after exposure
Tear IL-8 secretion was significantly inhibited in the unexposed controls with ocular surface abnormalities, while these inhibitory responses were not encountered in SM-exposed cases with ophthalmic surface abnormalities.
Alterations in the serum levels of chemokines 20 years after sulfur mustard exposure: Sardasht-Iran Cohort Study.
Elevated levels of MCP-1/CCL2 may suggest an anti inflammatory response and decreased levels of IL-8/CXCL8 and RANTES/ CCL5 may represent a different pathophysiology and diverse molecular mechanisms involved in long term clinical manifestations of SM exposure.
Inflammatory Markers in the Tears of Patients with Ocular Surface Disease
Levels of pro-MMP-9 levels in tears are elevated in all of the studied pathologies especially in ocular allergy and conjunctivochalasis, however, IL-1β and IL-6 were only found to be overexpressed in conjunctivaochalases.
Alterations in the serum levels of soluble L, P and E-selectin 20 years after sulfur mustard exposure: Sardasht-Iran Cohort Study.
The change in the pattern of selectins in the SM exposed group in comparison to the control group may indicate suppressed acute inflammatory condition in which new remodeling of cytokine expression play a more crucial role in the immune-regulation.
Tear cytokine profiles in dysfunctional tear syndrome.
Patients with DTS have higher levels of inflammatory mediators in their tears that show correlation with clinical disease parameters and significant correlations were observed between IL-6 and irritation symptoms and between a number of cytokines and chemokines and clinical parameters.
Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
A positive association between serum levels of pro-inflammatory cytokines (IL-1β,IL-8, IL-12 and RANTES) and acne among SM-exposed population is found.
Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease
The results suggest that inflammation plays a role not only in severe DED but also in moderate evaporative DED, and fracktalkine was demonstrated to be present and elevated in tears in human DED.
CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD
The results show a down regulation of CX3CR1 on CD8+ cells; this correlated to a low expression of CCR2 on CD9+ cells, which is in line with the role of this cell type in AMD development.
Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE.
The data suggest that CCL2/MCP-1, CCL3/MIP-1alpha, and CCL4/Mip-beta contribute to the recruitment of inflammatory cells into the eye and CNS and to disease activity.
MCP-1 and RANTES are mediators of acute and chronic inflammation.
It is reported that in experimental studies RANTES and MCP-1 provoke mast cell activation and increase histidine decarboxylase mRNA expression in a dose-dependent manner, and a new mechanism of pulmonary airway inflammation is proposed for the first time.