Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis.

  title={Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis.},
  author={Andrea Leonardi and Peter J. Jose and Hong Zhan and Virginia L. Calder},
  volume={110 3},

Antibody Array-Generated Cytokine Profiles of Tears of Patients with Vernal Keratoconjunctivitis or Giant Papillary Conjunctivitis

The present study demonstrated the presence of crucial cytokines, soluble cytokine receptors, and chemokines in tears of patients with VKC and GPC, and eotaxin-2 may play an important role in eosinophilic inflammation in VKC.

Evaluation of eotaxin-1, -2, and -3 protein production and messenger RNA expression in patients with vernal keratoconjunctivitis

It is shown that the mRNA expression and the protein production of the eotaxin subfamily at the ocular surface are critical biomarkers when investigating the pathophysiology of eosinophilic inflammation and the effect of antiallergic treatment in patients with VKC.

Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis

Purpose of reviewThe purpose of this review is to describe the new immunopathologic features of vernal keratoconjunctivitis: the involvement of cytokines, growth factors, cells, mediators and

Suppressive Effects of Tranilast on Eotaxin-1 Production from Cultured Conjunctival Fibroblasts

The results suggest that the anti-allergic effect of tranilast may be partly due to the inhibition of eotaxin-1 production from conjunctival fibroblasts.

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.

Th1- and Th2-type cytokines in chronic ocular allergy

Although both IL-4 and IFNγ are detected in tears, onlyIFNγ levels correlated with disease severity and upregulated ICAM-1 on conjunctival fibroblasts, suggesting the role of IFnγ in the inflammatory phase of chronic allergic eye diseases.

Histamine H1 and H4 receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases.

Relationship between tear eotaxin-2 and MMP-9 with ocular allergy and corneal topography in keratoconus patients

The tear MMP-9 level was higher in the keratoconic eyes, and it showed a correlation with the stage of the disease and the corneal thickness, and the tear eotaxin-2 did not exhibit any difference in the presence of keratoconus.

Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis

CCL24 (eotaxin-2) mRNA expression levels on the ocular surface are a useful biomarker for clinical severity of VKC/AKC.



Procollagens and inflammatory cytokine concentrations in tarsal and limbal vernal keratoconjunctivitis.

Increased levels of TGF-beta 1, IL-1 and IL-6 in VKC tissues and tears indicate a local production of these cytokines in active VKC, and PICP and PIIIP were significantly increased in tarsal VKC compared to both limbal VKC and controls.

Chemokines in the limbal form of vernal keratoconjunctivitis

An increase in the expression of RANTES, eotaxin, MCP-1, and MCP -3 in the conjunctiva of patients with VKC compared with control subjects suggests a potential role for these chemokines in the pathogenesis of VKC.

IL-4 Induces Eotaxin Production in Corneal Keratocytes but Not in Epithelial Cells

The results suggest that eotaxin production in keratocytes induced by IL-4 may play an important role in eosinophil recruitment to corneal ulcers in allergic ocular disease.

Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry.

Although results of systemic allergic markers can be inconclusive in patients with VKC, flow cytometry demonstrated a local lymphocyte phenotype that can account for the clinical and histologic abnormalities of VKC.

Histamine effects on conjunctival fibroblasts from patients with vernal conjunctivitis.

Investigation of the histamine reactivity of conjunctival fibroblasts derived from VKC patients showed that histamine is at least partially responsible for fibroblast stimulation, and H1 and H2 antagonists did not modify histamine-stimulated PIP production.

IL-4 induces eotaxin: a possible mechanism of selective eosinophil recruitment in helminth infection and atopy.

The hypothesis that eosinophil recruitment seen in IL-4-mediated skin reactions, at least in part, may be due to Th2 cytokine-mediated induction of eotaxin in dermal fibroblasts is supported.

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation

Evidence was obtained that eotaxin shares a binding site with RANTES on guinea pig eosinophils, which suggests the possibility that similar molecules may be important in the human asthmatic lung.

Growth factors and collagen distribution in vernal keratoconjunctivitis.

In giant papillae of VKC, the extracellular matrix is characterized by overproduction of collagens, and Expression of growth factors in the conjunctiva by resident cells (mast cells, epithelial cells, endothelial cells) and inflammatory cells (macrophages, eosinophils) may contribute to Papillae formation and fibrosis evolution in chronic ocular allergic diseases.