Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis.

@article{Leonardi2003TearAM,
  title={Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis.},
  author={Andrea Leonardi and Peter J. Jose and Hong Zhan and Virginia L. Calder},
  journal={Ophthalmology},
  year={2003},
  volume={110 3},
  pages={
          487-92
        }
}
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134 Citations
Highly Influential Citations
4
Background Citations
37
Methods Citations
1
Results Citations
5

134 Citations

Antibody Array-Generated Cytokine Profiles of Tears of Patients with Vernal Keratoconjunctivitis or Giant Papillary Conjunctivitis

The present study demonstrated the presence of crucial cytokines, soluble cytokine receptors, and chemokines in tears of patients with VKC and GPC, and eotaxin-2 may play an important role in eosinophilic inflammation in VKC.

Evaluation of eotaxin-1, -2, and -3 protein production and messenger RNA expression in patients with vernal keratoconjunctivitis

It is shown that the mRNA expression and the protein production of the eotaxin subfamily at the ocular surface are critical biomarkers when investigating the pathophysiology of eosinophilic inflammation and the effect of antiallergic treatment in patients with VKC.

Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis

Purpose of reviewThe purpose of this review is to describe the new immunopathologic features of vernal keratoconjunctivitis: the involvement of cytokines, growth factors, cells, mediators and…

Suppressive Effects of Tranilast on Eotaxin-1 Production from Cultured Conjunctival Fibroblasts

The results suggest that the anti-allergic effect of tranilast may be partly due to the inhibition of eotaxin-1 production from conjunctival fibroblasts.

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.

Th1- and Th2-type cytokines in chronic ocular allergy

Although both IL-4 and IFNγ are detected in tears, onlyIFNγ levels correlated with disease severity and upregulated ICAM-1 on conjunctival fibroblasts, suggesting the role of IFnγ in the inflammatory phase of chronic allergic eye diseases.

Histamine H1 and H4 receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases.

Relationship between tear eotaxin-2 and MMP-9 with ocular allergy and corneal topography in keratoconus patients

The tear MMP-9 level was higher in the keratoconic eyes, and it showed a correlation with the stage of the disease and the corneal thickness, and the tear eotaxin-2 did not exhibit any difference in the presence of keratoconus.

Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis

Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis

CCL24 (eotaxin-2) mRNA expression levels on the ocular surface are a useful biomarker for clinical severity of VKC/AKC.
...

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