Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease.

  title={Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease.},
  author={David C Jackson and Weiguang Zeng and Chinn Yi Wong and Edin Jessica Mifsud and Nicholas Williamson and Ching-Seng Ang and Algis Jonas Vingrys and Laura Elizabeth Downie},
  journal={Investigative ophthalmology & visual science},
  volume={57 11},
Purpose To assess whether tear hyperosmolarity, being diagnostic of dry eye disease (DED), is associated with specific alterations to the cytokine content of human tears that may provide a biomarker for DED. Methods In this prospective, cross-sectional, clinical study, participants (n = 77) were recruited from a single clinical site and categorized into groups based upon tear osmolarity status (n = 62 hyperosmolar, n = 15 normo-osmolar). Comprehensive anterior eye clinical assessments were… CONTINUE READING
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