Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans.

@article{NavarroMartnez2006TeaPE,
  title={Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans.},
  author={Mar{\'i}a Dolores Navarro-Mart{\'i}nez and Francisco Garc{\'i}a-C{\'a}novas and Jos{\'e} Neptuno Rodr{\'i}guez-L{\'o}pez},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={57 6},
  pages={
          1083-92
        }
}
OBJECTIVES Elucidation of the mechanism of action of epigallocatechin-3-gallate (EGCG) against Candida albicans and demonstration of the connection between its antifolate activity and other metabolic pathways involved in C. albicans survival are the major objectives of this study. METHODS C. albicans ATCC 10231 and 12 clinical isolates were used. MICs of EGCG against C. albicans were determined according to NCCLS. C. albicans dihydrofolate reductase (DHFR) was purified using methotrexate… 
Synergistic effects of tea catechin epigallocatechin gallate and antimycotics against oral Candida species.
TLDR
EGCG enhances the antifungal effects of miconazole, fluconazole and amphotericin B, thus preventing adverse effects and the emergence of drug-resistant oral Candida species.
Synergistic effects of tea polyphenol epigallocatechin 3-O-gallate and azole drugs against oral Candida isolates.
TLDR
EGCG synergistically enhanced the antifungal potential of azole drugs and might be helpful in preventing the development of drug resistance, in lowering the drug dosage, and thus minimizing adverse effects.
THE EFFECT OF (-)-EPIGALLOCATECHIN-3-GALLATE GREEN TEA ON NEUTROPHIL COUNT AND INFECTED CELLS BY CANDIDA ALBICANS IN A MURINE MODEL OF ORAL CANDIDIASIS
TLDR
EGCG green tea has been significantly increased neutrophil count and decreased infected cells by C. albicans in a murine model of oral candidiasis.
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TLDR
The results indicate that the molecules altering sterol profile may exert their antifungal effect through inhibition of ergosterol biosynthesis and could be good candidates for fungal specific drug development.
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TLDR
In vitro anticryptococcal effects of the leaf ethanolic extract of X. prockia leaf extract might indeed be a potential source of antifungal agents are evaluated and demonstrated that EAF was more selective for yeasts than was PBMCs.
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Aims: The contribution of natural compounds may provide significant progress in the discovery of new antifungal drugs. We aimed to investigate the contribution of carvacrol, farnesol,
Synergic anticandidal effect of epigallocatechin-O-gallate combined with amphotericin B in a murine model of disseminated candidiasis and its anticandidal mechanism.
  • Yongmoon Han
  • Biology, Medicine
    Biological & pharmaceutical bulletin
  • 2007
TLDR
Results indicate that EGCG, which has anticandidal activity causing blockage of the hyphal formation, has the synergism combined with Amp B against disseminated candidiasis.
Effect of active fraction of methanolic extract of Acorus calamus on sterol metabolism of Candida albicans
TLDR
The active fraction of methanolic extract of Acorus calamus effectively reduces ergosterol biosynthesis and thus prevents germ tube formation, finally causing cell death.
Anticandidal synergistic activity of green tea catechins, antimycotics and copper sulphate as a mean of combinational drug therapy against candidiasis.
TLDR
It can be inferred that present evaluated synergistic composition can confer promising anticandidal efficacy and requires further investigation of safety and translational guidelines for effective and safer green tea based potent therapeutic drug.
In vitro activity of 23 tea extractions and epigallocatechin gallate against Candida species.
TLDR
EGCG and other yet undefined substances in tea have differential antifungal activity in vitro against C.glabrata, C. albicans and C. parapsilosis, indicating that components of tea and EGCG might be useful particularly for the treatment of C. glabRata infections.
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TLDR
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TLDR
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TLDR
It is reported herein that (-)-epigallocatechin-3-gallate (EGCG), the major polyphenol from green tea, can inhibit DNMT activity and reactivate methylation-silenced genes in cancer cells and the potential use of EGCG for the prevention or reversal of related gene-silencing in the prevention of carcinogenesis is suggested.
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