Tea catechins and related polyphenols as anti-cancer agents.

@article{Isemura2000TeaCA,
  title={Tea catechins and related polyphenols as anti-cancer agents.},
  author={M. Isemura and K. Saeki and T. Kimura and S. Hayakawa and T. Minami and M. Sazuka},
  journal={BioFactors},
  year={2000},
  volume={13 1-4},
  pages={
          81-5
        }
}
Epigallocatechin gallate (EGCg) and theaflavins, a major constituent of green tea infusion and the constituents of black tea, respectively, were found to inhibit matrix metalloproteinases (MMPs) which are intimately associated with tumor invasion and metastasis. EGCg and related polyphenols exhibited apoptosis-inducing activity for several cancer cell lines including human stomach and colon cancer cells. Comparison of the activity of these compounds revealed the importance of the number and the… Expand
Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea
  • Y. Jung, L. Ellis
  • Medicine
  • International journal of experimental pathology
  • 2001
TLDR
Understanding the basic principles by which EGCG inhibits tumour invasion and angiogenesis may lead to the development of new therapeutic strategies, in addition to supporting the role of green tea as a cancer chemopreventive agent. Expand
Mechanisms of Inhibition of Tumor Angiogenesis and Vascular Tumor Growth by Epigallocatechin-3-Gallate
TLDR
The data suggest that the green tea gallate or its derivatives may find use in the prevention and treatment of vascular tumors in a chemoprevention or adjuvant setting. Expand
Protective role of green tea extract against genotoxic damage induced byanticancer drugs in cultured human lymphocytes.
Tea (Camellia sinensis) is one of the most popular beverages consumed worldwide as an infusion of leaves and is valued for its medicinal properties. Tea is a rich source of polyphenols calledExpand
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TLDR
This review summarizes several lines of evidence to indicate the health-promoting properties of green tea mainly based on the authors' own experimental findings. Expand
Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy
TLDR
The aim of this article is to discuss the E GCG molecule and its associated health benefits, particularly its anti-cancer activity and provide an overview of the studies that have employed nanotechnology strategies to enhance EGCG’s properties and potentiate itsAnti-tumoral activity. Expand
Green tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells.
TLDR
It is shown that EGCG inhibits topoisomersase I, but not topoisomerase II in several human colon carcinoma cell lines, for the first time. Expand
Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases.
TLDR
This review summarizes the mechanisms by which catechins play an essential role in regulating the process of carcinogenesis, with a special emphasis on how these catechin antagonize the growth factor-induced proliferative disorders. Expand
Epigallocatechin gallate from green tea exhibits potent anticancer effects in A-549 non-small lung cancer cells by inducing apoptosis, cell cycle arrest and inhibition of cell migration.
TLDR
Green tea (Camellia sinensis) is considered as a rich source of epigallocatechin gallate (EGCG) which has been shown to exert impressive pharmacological properties and it is believed that EGCG could prove to be an important lead molecule for the treatment of lung cancer. Expand
Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppression.
TLDR
EGCG is a potent proapoptotic agent in MCF-7 breast cancer cells that targets survivin expression via suppression of the AKT pathway and is supported to support the hypothesis that the inhibitory effect of EGCG on survivin is mediated via theAKT pathway. Expand
A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer.
TLDR
The O-acetylated (-)-EGCG analogs possessing a p-NH(2) or p-NHBoc (Boc; tert-butoxycarbonyl) D-ring (5 and 7) act as novel tumor cellular proteasome inhibitors and apoptosis inducers with potency similar to natural (-)- EGCG and similar to (--EGCG peracetate. Expand
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References

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Apoptosis-inducing activity of polyphenol compounds derived from tea catechins in human histiolytic lymphoma U937 cells.
TLDR
Polyphenolic compounds derived from tea catechins were examined for apoptosis-inducing activity in human histiolytic lymphoma U937 cells and the data suggest the importance of the number and three dimensional localization of their phenolic groups in this activity. Expand
Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts.
TLDR
EGCG at a concentration range of 40-200 microM induced a significant amount of apoptosis in WI38VA cultures, but not inWI38 cultures, as determined by terminal deoxynucleotidyl transferase assay. Expand
Induction of apoptosis in human stomach cancer cells by green tea catechins.
TLDR
The exposure of human stomach cancer KATO III cells to green tea catechin extract and epigallocatechin gallate led to both growth inhibition and the induction of programmed cell death (apoptosis). Expand
Inhibition of collagenases from mouse lung carcinoma cells by green tea catechins and black tea theaflavins.
TLDR
The results suggest that theaflavin, theAFlavin digallate, and (-)-epigallocatechin gallate inhibit tumor cell invasion by inhibiting type IV collagenases of the LL2-Lu3 cells. Expand
Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines.
TLDR
Epigallocatechin gallate, the main polyphenolic constituent of green tea, inhibits tumor promotion and chemical carcinogenesis in animal experimental systems and inhibited metastasis of B16 melanoma cell lines in both experimental and spontaneous systems. Expand
Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols.
TLDR
Tea polyphenol-induced production of H2O2 may mediate apoptosis and that this may contribute to the growth inhibitory activities of tea polyphenols in vitro. Expand
Black tea theaflavins induce programmed cell death in cultured human stomach cancer cells.
TLDR
Drinking of black tea in large amounts is recommended to protect humans from stomach cancer as exposure to black tea theaflavin extract led to both growth inhibition and the induction of programmed cell death (apoptosis). Expand
Apoptosis induced by tea polyphenols in HL-60 cells.
TLDR
The effects of tea polyphenols were shown to be similar to their cytotoxic activity in HL-60 cells, suggesting that the mechanism of antitumor action of teapolyphenols is related to its apoptosis-inducing activity. Expand
Induction of programmed cell death (apoptosis) in human lymphoid leukemia cells by catechin compounds.
TLDR
The exposure of human lymphoid leukemia Molt 4B cells to epigallocatechin (EGC), epig allocatechin gallate (EGCG), and persimmon extract containing all these catechin compounds led to both growth inhibition and the induction of programmed cell death (apoptosis). Expand
Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice.
TLDR
The results suggest that, although inhibition of the metabolic activation of NNK and the subsequent DNA alkylation by tea extracts can be demonstrated in vitro, this mechanism may not be important for the inhibitory action of tea against lung tumorigenesis. Expand
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