Tea catechins' affinity for human cannabinoid receptors.

  title={Tea catechins' affinity for human cannabinoid receptors.},
  author={Gabriele Korte and Andrea Dreiseitel and Peter Schreier and Anett Oehme and Sanja Locher and Sarah S Geiger and Joerg Heilmann and Philipp G. Sand},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={17 1},
Among the many known health benefits of tea catechins count anti-inflammatory and neuroprotective activities, as well as effects on the regulation of food intake. Here we address cannabimimetic bioactivity of catechin derivatives occurring in tea leaves as a possible cellular effector of these functionalities. Competitive radioligand binding assays using recombinant human cannabinoid receptors expressed in Chem-1 and CHO cells identified (-)-epigallocatechin-3-O-gallate, EGCG (K(i)=33.6 microM… CONTINUE READING
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