Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.

@article{Pekarsky2008Tcl1FA,
  title={Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.},
  author={Yuri Pekarsky and Alexey Palamarchuk and Vadim Maximov and Alexey Efanov and Natalya Nazaryan and Urmila Santanam and Laura Z. Rassenti and Thomas J. Kipps and Carlo M. Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 50},
  pages={19643-8}
}
B cell chronic lymphocytic leukemia (B-CLL) is the most common human leukemia. Deregulation of the T cell leukemia/lymphoma 1 (TCL1) oncogene in mouse B cells causes a CD5-positive leukemia similar to aggressive human B-CLLs. To examine the mechanisms by which Tcl1 protein exerts oncogenic activity in B cells, we investigated the effect of Tcl1 expression on NF-kappaB and activator protein 1 (AP-1) activity. We found that Tcl1 physically interacts with c-Jun, JunB, and c-Fos and inhibits AP-1… CONTINUE READING

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