Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.

  title={Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.},
  author={Yuri Pekarsky and Urmila Santanam and Amelia Cimmino and Alexey Palamarchuk and Alexey Efanov and Vadim Maximov and Stefano Volinia and Hansjuerg Alder and Chang-gong Liu and Laura Z. Rassenti and George A. Calin and John P. Hagan and Thomas J. Kipps and Carlo M. Croce},
  journal={Cancer research},
  volume={66 24},
B-cell chronic lymphocytic leukemia (B-CLL) is the most common human leukemia in the world. Deregulation of the TCL1 oncogene is a causal event in the pathogenesis of the aggressive form of this disease as was verified by using animal models. To study the mechanism of Tcl1 regulation in CLL, we carried out microRNA expression profiling of three types of CLL: indolent CLL, aggressive CLL, and aggressive CLL showing 11q deletion. We identified distinct microRNA signatures corresponding to each… CONTINUE READING
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that correlates with molecular subtypes and proliferative state

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